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KMID : 0525720160210040261
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Journal of Chitin and Chitosan
2016 Volume.21 No. 4 p.261 ~ p.266
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Anti-proliferative Effect of Eight Ethanolic Extracts from Soft Corals on Human Leukemia Cell Line HL-60
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Sanjeewa K. K. Asanka
Oh Jae-Young
Fernando I. P. S.
Lee Won-Woo
Kim Seo-Yong
Wang Lei
Jeon You-Jin
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Abstract
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In the present study, authors evaluate the anticancer effects of eight crude extracts from 70% ethanol extracts of soft corals collected around Jeju Island, South Korea. According to the cytotoxicity results, extracts are not cytotoxic to Vero cells at the highest tested concentration (100 μg/mL), which indicates that they are not cytotoxic to the normal cells. However, one of the tested extracts, Dendronephthya gigantea (DGI) extract, significantly reduced the viability of human leukemia cell line (HL-60) with IC50 value of 84.43 μg/mL. In addition, Hoechst 33342 cell permeable dye used to visualize the apoptotic nuclei in DGItreated HL-60 cells. These results suggest that DGI has the potential to induce apoptosis in HL-60 cells without altering viability of normal Vero cells. In conclusion, DGI might have the great potential to be developed into an anticancer drug in the future.
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KEYWORD
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Dendronephthya gigantean, HL-60, 70% ethanol extracts, Apoptosis
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